Chalk up another tragic ending connected to Bernard Madoff’s con - and another door likely nailed shut for investigators.

Ruth Madoff may never be prosecuted in connection with her husband’s decades-long Ponzi scheme, but her days living “a life of splendor” could be over.

It looks like court-appointed Madoff trustee Irving Picard is going after the whole shebang: Not just Bernard Madoff’s Manhattan penthouse and home in the Hamptons, but also a good chunk of the wealth accumulated by family members.

Jewish philanthropist Stanley Chais was one of Bernard Madoff’s earliest investors, steering tens of millions of dollars of other people’s money to the convicted swindler.